New 2026 Research Is Shaking Up What We Thought We Knew About Facial Aging
— And You Can Do Something About It
For decades, skincare pointed you toward one thing: your skin. A new 2026 scientific study by Lee, Zamin, Yi, et al., published in JPRAS Open, suggests the real story may be happening somewhere no cream, serum, or retinoid was ever built to reach — the bone structure underneath it.
The bones beneath the skin's surface don't stay still as we age — researchers are increasingly asking why nobody talks about it.
Here's exactly what researchers measured:
Using data from this research, we can estimate how these changes may already be showing up on your own face — and project how they may affect you in the years ahead.
Methodology & Sources
Where These Numbers Come From
All figures are anchored to Lee, Zamin, Yi, et al., "Facial bone aging: An update and literature review," JPRAS Open, 2026 — a synthesis of 72 studies (2020–2023). The review reports orbital enlargement of 15–20%, maxillary height decrease of 8–15%, and mandibular angle increase of 3–7°, each measured cumulatively by the 7th decade of life (around age 70).
How We Personalize By Sex
- Orbital: Anderson et al. (3D CT, n=450, ages 20–80) found 23% greater orbital change in women, used to split the review's range into separate estimates by sex.
- Maxillary: Patel et al. (CBCT, n=320) found 35% greater resorption in postmenopausal women, used the same way.
- Mandibular: Rodriguez et al. (n=380, ages 25–75) describes this change as more pronounced in men, though without a specific ratio — so pacing, not the endpoint, differs by sex here.
Why The Curve Isn't A Straight Line
Longitudinal research found these changes accelerate around a woman's 40s–50s — consistent with the hormonal shifts of perimenopause — and progress more gradually in men. That acceleration pattern, not a flat per-year rate, is what's modeled here.
What This Estimate Is — And Isn't
This is a population-level model built from published research, personalized to your age, sex, and (if applicable) menopause status. It is not a measurement of your own bone structure and not a medical or diagnostic assessment.
Based on a 2026 peer-reviewed literature review of 72 studies. Your results are estimates from published population research, not a personal measurement.
Tell Us A Bit About Yourself
Research shows facial bone change differs by sex and progresses with age — we'll use this to personalize what comes next.
Have You Noticed Any Of These Changes?
Select all that apply.
Orbital Enlargement
The bony socket around your eyes gradually widens with age — one of the main reasons eyes can look more hollow, shadowed, or lined.
Maxillary Height Loss
Your upper jawbone — the structural support behind your cheeks — gradually loses height, which is part of why cheeks flatten and lose their lift, and why the lines from your nose to your mouth can look deeper.
Mandibular Angle Change
The angle of your jawbone widens over time, which is part of why jawlines soften and lose definition — a common reason for jowls and sagging along the lower face.
The Science Has Been Building.
Your estimates above draw on a 2026 review of 72 studies — but the pattern itself has been documented for years.
Major research described skeletal resorption in the orbital rim, midface, and mandible — and said deficiencies in the facial skeletal foundation contribute to features of the aging face.
Researchers described facial aging as intertwined changes involving bone, ligaments, muscles, fat, fascia and skin.
Clinical research again described facial aging as involving alterations in skin, soft tissue, and the bony skeleton.
A dedicated analysis pulled together contemporary evidence and quantified measurable skeletal changes across the orbit, maxilla, and mandible.
The Science Has Been Building.
The skincare conversation is only beginning to catch up.
How Much Have You Spent Taking Care Of Your Skin?
Creams. Serums. Retinoids. Peptides. Masks. Treatments.
All focused on what you can see at or near the surface.
But Modern Research Says Facial Aging Is Much Bigger Than Skin.
You've spent years caring for the surface.
What have you been doing for the structural foundation underneath it?
Does Anything In Your Current Routine Specifically Support Your Facial Structure From Within?
Most People Don't.
For decades, the facial-aging conversation has centered largely on what happens at the surface.
Meet FaceFrame®.
FaceFrame was developed around the overlooked structural side of the equation — a patent-pending AM/PM supplement system designed to complement skincare by providing nutrients involved in bone metabolism, collagen formation and connective tissue support from within.*
Clinically linked to measurable increases in bone mineral density.
Activates osteocalcin, the protein responsible for building new bone matrix.
Plays a role in how the body metabolizes the minerals that build bone.
Studied for its role in supporting osteoblast activity, the cells responsible for building new bone.
Supports the connective tissue components of facial structure.
One of the two amino acids most concentrated in the body's own collagen structure.
Supports normal bone mineral density throughout the skeletal system, including the bones that shape your face.
A cofactor your body needs to cross-link and strengthen collagen fibers.
Supports the enzymes involved in forming and maintaining connective tissue.
The core amino acid building block your body uses to make collagen.
Studied alongside strontium and MK-7 for its combined effect on bone density.
A required cofactor for your body's own collagen production.
A cofactor involved in bone mineralization and collagen formation.
Formulated as a coordinated system — timed to work together, not as isolated inputs.
Pending
in USA
Compliant
Guarantee
Every batch of the AM and PM formulas is tested against a full Certificate of Analysis before release. Testing covers identity verification (confirming the blend matches its reference standard), potency testing to confirm every active ingredient falls within its target range, microbiological testing (including confirmed absence of Salmonella, E. coli, Staphylococcus aureus, and Pseudomonas aeruginosa), and heavy metal screening for mercury, lead, arsenic, and cadmium — each verified well within allowable limits. Both current lots passed every test.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Your Routine Is Ready.
One Thing Is Missing.
You're already caring for your skin. FaceFrame completes your routine by supporting the structural layer beneath it.*
Every batch of the AM and PM formulas is tested against a full Certificate of Analysis before release. Testing covers identity verification (confirming the blend matches its reference standard), potency testing to confirm every active ingredient falls within its target range, microbiological testing (including confirmed absence of Salmonella, E. coli, Staphylococcus aureus, and Pseudomonas aeruginosa), and heavy metal screening for mercury, lead, arsenic, and cadmium — each verified well within allowable limits. Both current lots passed every test.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.