You already know skin changes with age.
But the structures beneath your skin change too, including the connective tissue and bone that help shape and support your face.
What you see in the mirror is shaped by multiple layers working together.
All of these structures naturally change with age.
Age-related changes beneath the skin can influence:
That's one reason caring for the skin alone may not address every visible change associated with aging.
For decades, facial aging research focused almost entirely on the skin — wrinkles, elasticity, hydration. In 2026, a scientific study published in JPRAS Open pulled together the growing body of imaging research and reached a striking conclusion: the bones beneath your skin never stop changing shape — reshaping the face from the inside out, independent of anything happening at the surface.
"The bones in the face lose volume and recede a little bit as we age. Women lose facial bone volume at a younger age than men, causing them to see the signs of aging sooner."
— Dr. David Kahn, MD · Plastic Surgeon, American Society of Plastic Surgeons



And it isn't an isolated finding. Imaging and skeletal research has been building toward this same conclusion for years:
AI-assisted 3D shape analysis maps how the jawbone changes shape with age.
Skeletal analysis reaches the same conclusion using physical bone records instead of imaging.
Described facial aging as intertwined changes involving bone, ligaments, muscles, fat, fascia and skin.
Major research described skeletal resorption in the orbital rim, midface, and mandible — and said deficiencies in the facial skeletal foundation contribute to features of the aging face.
3D CT imaging confirms measurable orbital bone changes with age.
CT imaging identifies a "clockwise rotation" pattern in the aging facial skeleton.
The evidence keeps pointing to the same place: what's happening beneath the skin matters as much as what's happening on it.
Creams and serums are designed to work at or near the skin's surface. But facial structure involves more than skin alone.
What if your daily routine supported both?
FaceFrame® is a patent-pending daily AM/PM supplement system developed to complement your skincare routine by supporting the structures beneath the surface.*
Ingredients selected to support bone metabolism, collagen formation and connective tissue.
Complementary ingredients designed to continue structural nutritional support as part of your nightly routine.
The FaceFrame AM/PM system is built around a set of ingredients, each selected for its documented role in bone density, collagen formation, or connective tissue support.*
Clinically linked to measurable increases in bone mineral density.
Activates osteocalcin, a protein involved in building new bone matrix.
Plays a role in how the body metabolizes minerals involved in bone.
Studied for its role in supporting osteoblast activity.
Supports connective tissue components of facial structure.
An amino acid highly concentrated in the body's collagen structure.
Supports normal bone mineral density throughout the skeletal system, including the bones that shape your face.
A cofactor your body needs to cross-link and strengthen collagen fibers.
Supports the enzymes involved in forming and maintaining connective tissue.
The core amino acid building block your body uses to make collagen.
Studied alongside strontium and MK-7 for its combined effect on bone density.
A required cofactor for your body's own collagen production.
A cofactor involved in bone mineralization and collagen formation.
A 3-year randomized, placebo-controlled trial in 244 postmenopausal women found that 180mcg/day of vitamin K2 (MK-7) significantly slowed age-related bone density loss at the spine and hip, and improved bone strength.
A 24-month randomized, placebo-controlled crossover trial (RESHAW) found that resveratrol supplementation improved bone mineral density at the spine and hip in postmenopausal women. The dose studied was higher than the amount in FaceFrame.
A one-year double-blind randomized trial in postmenopausal women studied a nightly combination of strontium citrate, vitamin D3, and vitamin K2 (MK-7), and found increased bone density at the spine and hip versus placebo. The studied combination also included melatonin, so these results can't be attributed to any single ingredient alone.
A randomized, placebo-controlled trial in 50 women with photodamaged facial skin found that daily silicon (as choline-stabilized orthosilicic acid) for 20 weeks improved skin roughness and mechanical properties versus placebo. FaceFrame uses a different silicon source (bamboo-derived silica).
A 16-week randomized, double-blind, placebo-controlled trial in 87 women aged 40–65 found that daily collagen with vitamin C improved skin density by about 16% versus placebo.
These are published studies on individual ingredients used in FaceFrame's formula — not clinical trials of the FaceFrame product itself.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
You've seen why facial aging involves more than skin alone. Now choose the FaceFrame routine that works best for you.
Every batch of the AM and PM formulas is tested against a full Certificate of Analysis before release. Testing covers identity verification (confirming the blend matches its reference standard), potency testing to confirm every active ingredient falls within its target range, microbiological testing (including confirmed absence of Salmonella, E. coli, Staphylococcus aureus, and Pseudomonas aeruginosa), and heavy metal screening for mercury, lead, arsenic, and cadmium — each verified well within allowable limits. Both current lots passed every test.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.